Intra-articular Injection of Autologous Protein Solution for Treatment of Canine Osteoarthritis PDF
By:Audrey Wysocki Wanstrath
Published on 2015 by
Osteoarthritis (OA) is a common cause of debilitating lameness in dogs. Although osteoarthritis is classified as a non-inflammatory disease, low levels of inflammation are present in the joint and can affect the progression of the disease. Osteoarthritis is characterized by degradation and loss of articular cartilage, osteophyte formation, subchondral bone sclerosis and inflammation of the synovial membrane. As cartilage begins to breakdown, the ratio of naturally occurring inflammatory to anti-inflammatory cytokines becomes imbalanced causing increased breakdown of cartilage. A novel method for up regulation of anti-inflammatory cytokines from whole blood has been reported which produces an autologous protein solution (APS). Injection of APS has been shown to be an effective treatment of OA in horses and has greater anti-inflammatory proteins than platelet-rich plasma, another protein solution used for treatment of OA. The objective of the study was to prospectively evaluate the efficacy of an intra-articular injection of APS for treatment of OA in dogs using the Canine Brief Pain Inventory (CBPI) to score pain, Hudson visual analog scale (HVAS) to score lameness, and peak vertical force (PVF) to evaluate weight-bearing. Twenty client-owned dogs with a unilateral lameness attributable to OA of the elbow or stifle were enrolled and randomly assigned to a joint injection with APS or 0.9% saline solution. Owners and observers performed assessments blinded prior to injection, and at week 2 and 12 after injection. Radiographs of the affected joint were made prior to injection and at week 12. For dogs that received the APS injection, lameness scores (improved 25.6%; P
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